5-MTHF (Available in 1 mg and 5 mg Strengths)

5-MTHF is the biologically active form of folate, the form your body can immediately utilize without requiring conversion by the MTHFR enzyme. Unlike synthetic folic acid, 5-MTHF bypasses the MTHFR conversion pathway and directly supports methylation, cardiovascular health, cognitive function, neurotransmitter production, cellular health, and healthy fetal development. This practitioner-grade formula is available in both 1 mg and 5 mg strengths to support individualized nutritional needs.

Highlights

• Available in 1 mg and 5 mg strengths
• Contains bioactive L-5-Methyltetrahydrofolate (5-MTHF)
• Ready for immediate use by the body
• Bypasses the MTHFR conversion step
• Supports methylation and homocysteine metabolism
• Practitioner-trusted Thorne formulation

How It Works

Folate plays a critical role in DNA synthesis, cellular repair, methylation, neurotransmitter production, and cardiovascular health. Many individuals have genetic variations that reduce their ability to convert folic acid into its active form. 5-MTHF provides the body's preferred active form of folate, eliminating the need for conversion and ensuring direct utilization. 

Methylation is involved in hundreds of biochemical processes throughout the body, including detoxification, hormone metabolism, neurotransmitter production, and gene expression. Adequate active folate supports these pathways while helping maintain healthy homocysteine levels already within the normal range.

5-MTHF also supports the production of important neurotransmitters including serotonin, dopamine, melatonin, and epinephrine, which play important roles in mood, cognition, sleep, and overall neurological function. 

Suggested Use

5-MTHF 1 mg: Take 1 capsule daily or as recommended by your health care professional.

5-MTHF 5 mg: Take 1 capsule daily or as recommended by your health care professional.

Higher-potency folate supplementation should be used under practitioner supervision.

Who It's For

• Individuals with MTHFR genetic variations
• Those seeking methylation support
• Adults looking to support cardiovascular wellness
• Individuals focused on cognitive and neurological health
• Women preparing for pregnancy or supporting prenatal nutrition
• Patients following practitioner-guided methylation protocols

Available Strengths

5-MTHF 1 mg
Ideal for foundational methylation support, daily folate supplementation, and individuals beginning an active folate protocol.

5-MTHF 5 mg
Higher-potency active folate support commonly utilized in practitioner-directed methylation, homocysteine, neurological, and reproductive wellness protocols. 

Important

Consult your physician before starting any new supplements, especially if you are pregnant, nursing, taking medication, managing a medical condition, or under medical supervision. Use only as directed by your health care professional.

FDA Disclaimer:
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.